Carl Jorns

Carl Jorns

Affiliated to Research | Docent
Visiting address: Hälsovägen, Enheten för transplantationskirurgi F82, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Transplantation, 141 52 Huddinge

About me

  • Associate Professor Carl Jorns, MD, PhD, is a transplant surgeon and academic clinician specialized in liver transplantation, organ donation, and regenerative medicine. He studied medicine at the Albert‑Ludwigs‑Universität Freiburg in Germany and completed his doctoral degree at the Department of Virology, where his thesis focused on interferon‑stimulated genes and antiviral host responses.

    Carl received his clinical surgical training in general surgery and transplantation surgery at Karolinska University Hospital in Stockholm. In parallel, he pursued research in cellular therapies and obtained his PhD from Karolinska Institutet in 2015, with a thesis centered on clinical and experimental hepatocyte transplantation and liver regeneration.

    Carl combines advanced clinical practice with translational research in liver replacement therapies, organ preservation, and approaches to expand the donor pool. He has authored numerous peer‑reviewed publications and collaborates within national and international research networks. He serves as supervisor and co‑supervisor for several PhD students in the fields of organ donation, transplantation, and regenerative medicine.

    Carl is currently the Head of Liver Transplantation at the Department of Transplantation Surgery, Karolinska University Hospital, where he leads the clinical liver transplant program and contributes to strategic development, research, and education within the field of abdominal transplantation.

Research

  • Carl Jorns’ research focuses on organ donation, liver transplantation, and regenerative medicine. His work includes neonatal organ donation, hepatocyte transplantation, and strategies to expand the donor pool. He has a particular interest in controlled and uncontrolled donation after circulatory death (cDCD and uDCD) and led the national implementation of normothermic regional perfusion (NRP) and DCD liver transplantation in Sweden.

    His translational research spans clinical and experimental studies in hepatocyte transplantation and methods to optimize donor organ utilization. He is also an investigator in the IHOPE consortium (Immunology of Human Organ Donors), which examines immunological characteristics of organ donors to better understand factors influencing graft function and transplant outcomes.

Teaching

  • Carl Jorns teaches within organ donation, transplantation surgery, and cell‑based regenerative therapies, closely integrated with his clinical role as transplant surgeon at Karolinska University Hospital. He provides clinical teaching for medical and nursing students, residents, and fellows, and contributes to undergraduate, graduate, and doctoral education at Karolinska Institutet. He supervises several PhD students and participates in postgraduate training programs.

    He serves as the Swedish delegate to the European Board of Surgery, Division of Transplantation Surgery, and was the Swedish partner in the EU‑funded TEODOR initiative developing training programs in organ donation and transplantation.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2026 - 31 December 2028
    Amyloid beta (Aβ) associated diseases, such as Alzheimer’s disease and cerebral amyloid angiopathy (CAA), have repeatedly been found to be experimentally transmissible in animals in a prion-like pattern. Recent studies also indicate that such transmission may occur iatrogenically also in routine medical care, following treatment with cadaveric growth hormone, brain surgery and possibly also following blood transfusion. Because diseases in the Aβ-associated spectrum are comparably common, the public health consequences of such transmission may be sizable, especially in organ and ocular tissue transplantation where donors often already have manifest such disease, given that these donors have commonly succumbed to catastrophic intracerebral hemorrhage, one of the hallmark features associated with CAA. Because outcomes following both organ and ocular tissue transplantation in recent years are very good, with large fractions of patients surviving several decades, Aβ transmission could lead to negative patient health effects even considering that incubation times are likely protracted. In this study we will establish a cohort of patients who have undergone solid organ or ocular tissue transplantation, together with data on the medical history of their donors, with the purpose of investigating whether evidence of Aβ proteinopathy in donors leads to an increased risk of Alzheimer’s disease or spontaneous intracerebral hemorrhage in their recipients.
  • Clinical implementation av neonatal organ donation
    Region Stockholm
    1 January 2026 - 1 January 2027
  • Uncovering Hypoxia-Adapted T Cell Receptors to Enhance Immunotherapy for Hepatocellular Carcinoma
    Center for Innovative Medicine
    1 January 2026 - 1 January 2028
  • Strategies to improve outcome in clinical liver transplantation
    Region Stockholm
    1 January 2026 - 1 January 2028
  • Klinisk Forskare
    Region Stockholm
    1 January 2024 - 1 January 2028
  • Swedish Research Council
    1 January 2023 - 31 December 2025
  • Immunology Human Organ Donor Programme (IHOPE)
    Knut and Alice Wallenberg Foundation
    1 January 2023 - 1 January 2028
  • Strategies to improve outcome in clinical liver transplantation
    Region Stockholm
    1 January 2023 - 1 January 2026
  • Enhancing safety and clinical efficacy of fertility preservation for women and men with cancer identifying disease-associated risks and improving cryopreservation and transplantation methods to recover fertility
    Region Stockholm
    1 January 2022 - 1 January 2024
  • Design av neoantigen-baserat vacciner mot levercancer
    Center for Innovative Medicine
    1 January 2022 - 1 January 2025

Employments

  • Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2025-2028

Degrees and Education

  • Docent, Karolinska Institutet, 2022
  • Degree Of Doctor Of Philosophy, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2015

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