Balans, gång, träning och fysisk aktivitet vid neurologiska sjukdomar – Franzéns forskargrupp

Translationell forskning från att utforska neuronala mekanismer till kliniska interventioner och implementering vid Parkinsons sjukdom, multipel skleros, stroke och ryggmärgsskada.

En del av:
Gruppbild på medlemmar i Erika Franzéns forskargrupp.

Forskningsfokus

Forskningsfokus ligger på translationell forskning från att utforska neuronala mekanismer till kliniska interventioner/implementering inom området neurologisk och geriatrisk rehabilitering. Våra specialintressen är balanskontroll, träning, fysisk aktivitet och fall hos äldre och individer med neurologiska sjukdomar som Parkinsons sjukdom, multipel skleros, stroke och ryggmärgsskada.

Mer information om vår forskargrupp finns på den engelska sidan.

Publikationer

Utvalda publikationer

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Finansiering

Forskningsbidrag

  • Motorisk-kognitiv funktion hos personer med multipel skleros - hjärnaktivitet och effekter på balans
    Norrbacka-Eugeniastiftelsen
    1 January 2024 - 31 December 2025
    Beskrivning/bakgrund: I projektets Fas 1 genomförs en experimentell studie. I Fas 2 kommer effekter av en intervention studeras i en randomiserad kontrollerad studie. Föreliggande ansökan avser projektets Fas 1. I den experimentella studien utförs tester av hjärnaktivitet under komplex gång. Testerna vid komplex gång sker när man går och samtidigt tänker på något annat. Kroppens rörelser registreras med rörelsemätare. Aktivitet i hjärnans mäts med funktionell nära-infraröd spektroskopi, likt en mössa med fastsatta ljussensorer. Kliniska tester av gång, balans och kognition sker. Förväntat antal: Totalt 40 personer från diagnosgrupp MS, som kan gå i 5 minuter med/utan hjälpmedel, åldersgrupp 18 år eller äldre deltar, samt 40 friska kontroller. Frågeställningar, Fas 1: 1. Vilka effekter på motorisk-kognitiv förmåga vid komplex gång, mätt med samtidig hjärnaktivitet (mätt med funktionell infraröd spektroskopi, fNIRS) och avancerad gånganalys (APDM), förekommer hos personer med multipel skleros (MS) jämfört med friska personer? 2. Hur kan motorisk-kognitiv förmåga under komplex gång associeras med underliggande hjärnfunktion (mätt med fNIRS) hos personer med MS?
  • Linking behavioural effects of intensive motor-cognitive exercise to biomarkers in people with neurological diseases
    Strategiska forskningsområdet vårdvetenskap (SFO-V)
    1 September 2023 - 31 August 2025
  • Swedish Research Council for Health Working Life and Welfare
    1 July 2023 - 30 June 2026
    Older people with Parkinson’s disease (PD) are one of the frailest groups in society, as debilitating symptoms place them at high risk for physical inactivity, social withdrawal and reduced quality of life. PD symptoms also lead to emotional and communicative changes which can severely affect social functioning and result in loneliness and stigmatization.  The proposal outlines five studies which ultimately aim to increase the accessibility and success of implementing evidence-based welfare technology to support active and dignified ageing with PD, and also older adults requiring support for chronic disease.   Research goals are:To investigate the efficacy of eHealth delivered motor-cognitive home training with regards to functional capacity, motor-cognitive ability, and physical activity behaviour, by performing a randomised controlled trial.To investigate how the use of novel wearable technologies can enhance the assessment of motor-cognitive performance in PD. To investigate patterns of participation in places for activities outside of the home among people with PD, and to explore how use of eHealth and other factors are associated with these patterns.To explore and describe perceptions of carers to people with PD regarding the potential for eHealth technology to support everyday life and participation.To investigate health care professional’s perspectives on determinant factors for the implementation of welfare technology for the care older adults with chronic diseaseOur methods will span a variety of designs and methods - a randomised control trial (RCT), cross-sectional observational studies and qualitative data collection. We will also investigate perceptions of welfare technology from multiple perspectives, including carers to people with PD and a wide range of health care personnel.  Findings from these studies will have direct relevance for older people living with chronic and progressive disease, their relatives or carers and for the future implementers of welfare technology- health care providers specialised in the care of older adults. The project group is multi-professional and incorporates physiotherapists, a Neurologist MD, occupational therapists and neuropsychologists. The planned studied are in conjuntion with clinical Geriatric hospital, which ensures timely implementation of findings. Studies 1 (RCT) and 2 (cross-ectional) are underway (commenced Oct 2022), all remaining studies studies are planned to be completed by summer 2026.
  • Brain activation during complex walking and cognitive dual-tasking in people with multiple sclerosis
    NEURO
    15 January 2023 - 31 December 2023
  • Swedish Research Council
    1 January 2023 - 31 December 2026
    Life means combining motor-cognitive skills, e.g., walking, talking and navigating. Aging or neurological diseases, e.g., Parkinson’s disease (PD) compromises these skills needed for an independent life. It is uncertain which brain alterations lead to these difficulties and how to target these heterogenous motor-cognitive difficulties. Current treatments apply a "one-size-fits-all" approach, which needs to evolve towards personalized rehabilitation, reaching beyond a simple adaption to disease severity.Our multimodal project combines physiotherapy, neurology, psychology and neuroimaging to characterize motor-cognitive skills during complex walking, identify underlying brain alterations and subtype PD to inform a novel exercise approach for people with PD. This 5 years proposal has 4 stages: 1) Exploring brain alterations and links to the motor-cognitive skills in healthy and PD 2) PD subtyping using neuroimaging, motor, cognitive and clinical data 3) Characterization of exercise responsiveness in PD and 4) Development and testing of a personalized motor-cognitive exercise program. We combine novel techniques for data collection with in-depth analysis of existing data (EXPANd trial). The results will have an immediate application and clinical relevance for personalized rehabilitation in older and PD. There is no cure for PD yet, thus positive findings would revolutionize treatment, giving new hope to patients for a life with improved health, independence and higher quality.
  • Limitations in balance and walking in people with multiple sclerosis – an intervention study based on mechanistic research and co-design
    Stiftelsen Promobilia
    1 June 2022 - 1 June 2023
  • A study of highly challenging balance training including motor/cognitive dual-task in people with MS
    NEURO
    1 September 2021 - 31 August 2022
  • Balance and gait during complex activities in people with multiple sclerosis and the experiences of limited balance
    Stiftelsen Promobilia
    1 January 2020 - 31 December 2021
  • Balance and gait during complex activities in people with multiple sclerosis and the experiences of limited balance
    NEURO
    1 May 2019 - 31 December 2022
  • Swedish Research Council
    1 January 2017 - 31 December 2020
  • Swedish Research Council for Health Working Life and Welfare
    1 December 2014 - 30 November 2017
  • Swedish Research Council
    1 January 2013 - 31 December 2016
  • Swedish Research Council
    1 January 2011 - 31 December 2014
  • Swedish Research Council
    1 January 2011 - 31 December 2013
  • Swedish Research Council
    1 January 2011 - 31 December 2014

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  • Agoriwo, Mary