Molekylär och cellulär arbetsfysiologi – Ruas lab

Publikationer

Utvalda publikationer

Editorial: CELL. 2022;185(8):1444-1444.e1
Regulation and biology of PGC-1α
Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
Article: CELL METABOLISM. 2021;33(11):2215-2230.e8
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
Article: METABOLITES. 2021;11(8):508
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476
Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats
Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
Editorial: SCIENCE. 2020;368(6490):470-471
Exercised cytokines promote endurance
Correia JC; Ruas JL
Article: SKELETAL MUSCLE. 2019;9(1):26
LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force
Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
Article: NATURE COMMUNICATIONS. 2019;10(1):2767
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
Article: MOLECULAR METABOLISM. 2018;9:28-42
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration
Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
Article: CELL METABOLISM. 2018;27(2):378-392.e5
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Review: SCIENCE. 2017;357(6349):eaaf9794
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health
Cervenka I; Agudelo LZ; Ruas JL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184
Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes
Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
Article: MOLECULAR METABOLISM. 2015;4(12):891-902
Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Review: DIABETOLOGIA. 2015;58(9):1969-1977
The hitchhiker's guide to PGC-1α isoform structure and biological functions
Martinez-Redondo V; Pettersson AT; Ruas JL
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314
Intercellular: local and systemic actions of skeletal muscle PGC-1s
Correia JC; Ferreira DMS; Ruas JL
Article: CELL. 2014;159(1):33-45
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167
Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL

Alla gruppmedlemmars publikationer

Journal article: CELL REPORTS. 2025;44(12):116613
Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity
Dumont KD; Seradj S; Wang Y; Liu S; Cervenka I; Wu C; Jannig PR; Porsmyr-Palmertz M; Baiges-Gaya G; Huang X; Nihlen C; Dias JM; Skiotyte SS; Praestholm SM; Wilbert D; Leuchtmann AB; Quinn MA; Zhu Z; Hepler C; Lundberg JO; Teixeira AI; Rosenzweig A; Wu J; Ye L; Ruas JL
Journal article: CIRCULATION. 2025;152(Suppl_3):a4344599
Abstract 4344599: Converging Mechanisms in Divergent Cardiomyopathies: FSCN1 as a Druggable Epigenetic-Mitochondrial Target in Heart Failure
Yuan Z; He J; Zhu Z; Chen R; Shang L; Szczeniak D; Seidman J; Seidman C; Ruas J; Rosenzweig A
Review: NATURE METABOLISM. 2025;7(5):875-894
Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution
Loft A; Emont MP; Weinstock A; Divoux A; Ghosh A; Wagner A; Hertzel AV; Maniyadath B; Deplancke B; Liu B; Scheele C; Lumeng C; Ding C; Ma C; Wolfrum C; Strieder-Barboza C; Li C; Truong DD; Bernlohr DA; Stener-Victorin E; Kershaw EE; Yeger-Lotem E; Shamsi F; Hui HX; Camara H; Zhong J; Kalucka J; Ludwig JA; Semon JA; Jalkanen J; Whytock KL; Dumont KD; Sparks LM; Muir LA; Fang L; Massier L; Saraiva LR; Beyer MD; Jeschke MG; Mori MA; Boroni M; Walsh MJ; Patti M-E; Lynes MD; Blueher M; Ryden M; Hamda N; Solimini NL; Mejhert N; Gao P; Gupta RK; Murphy R; Pirouzpanah S; Corvera S; Tang S; Das SK; Schmidt SF; Zhang T; Nelson TM; O'Sullivan TE; Efthymiou V; Wang W; Tong Y; Tseng Y-H; Mandrup S; Rosen ED
Article: SKELETAL MUSCLE. 2025;15(1):9
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1-and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Stroemlind H; Moberg M; Edman S; Soederlund K; Checa A; Ruas JL; Blomstrand E
Doctoral thesis: 2025
Inter-organ communication and metabolic regulators of adipose tissue and skeletal muscle
Dumont K
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2025;328(2):E274-E285
Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism
Dumont KD; Jannig PR; Porsmyr-Palmertz M; Ruas JL
Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373
Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
Article: ACTA DERMATO-VENEREOLOGICA. 2024;104:adv40796
Risk Factors Associated with Weight Gain during Treatment with Dupilumab among Patients with Moderate to Severe Atopic Dermatitis
Tayefi M; Svedbom A; Ivert LU; Lundqvist M; Ruas JL; Bradley M; Johansson EK
Article: NATURE COMMUNICATIONS. 2024;15(1):9826
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Pham TCP; Raun SH; Havula E; Henriquez-Olguin C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig PR; Andersen NR; Kruse R; Ali MS; Irazoki A; Halling JF; Ringholm S; Needham EJ; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ortenblad N; Hojlund K; Kjaer M; Ruas JL; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;224:s9-s10
Exploring the Connection Between Chronic Inflammation, NR4A3, and Mitochondrial Deficiency in Skeletal muscle
Alves ES; van Deventer A; Jude B; Shorter E; Smith J; Steinz M; Gustafsson T; Rullman E; von Walden F; Svensson C; Zierath JR; Ruas JL; Lanner J
Article: AGING CELL. 2024;23(11):e14295
Senescence detection using reflected light
Dedic B; Westerberg L; Solis AM; Dumont KD; Ruas JL; Thorell A; Naslund E; Spalding KL
Preprint: BIORXIV. 2024
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015
Mood, Cognitive Function, and Plasma Kynurenine Metabolites Responses Following Severe Changes in Physical Activity
Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
Journal article: ELIFE. 2024;12
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: ELIFE. 2024;12:rp92707
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(34):e2319724121
Zfp697 is an RNA- binding protein that regulates skeletal muscle inflammation and remodeling
Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Praestholm SM; Dias JM; Dumont KD; Liu Z; Liang Q; Edsgaerd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Teixeira AI; Yeo GW; Ruas JL
Article: MOLECULAR METABOLISM. 2024;82:101912
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Preprint: RESEARCH SQUARE. 2024
The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Sylow L; Pham TCP; Raun S; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen A; Jannig P; Andersen N; Kruse R; Ali M; Halling J; Ringholm S; Needham E; Hansen S; Lemminger A; Schjerling P; Petersen M; de Almeida M; Jensen T; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski J; Nielsen J; Qvortrup K; Pilegaard H; Richter E
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2024;103(1):151377
Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration
Nunes MJ; Carvalho AN; Sa-Lemos C; Colaco M; Cervenka I; Ciraci V; Santos SG; Ribeiro MM; Castanheira M; Jannig PR; Gama MJ; Castro-Caldas M; Rodrigues CMP; Rodrigues E; Ruas JL
Journal article: NATURE NANOTECHNOLOGY. 2024;19(2)
Multivalent insulin receptor activation using insulin-DNA origami nanostructures
Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(2):166980
NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease
Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Gama MJ; Castro-Caldas M; Rodrigues CMP; Ruas JL; Rodrigues E
Article: NATURE NANOTECHNOLOGY. 2024;19(2):237-245
Multivalent insulin receptor activation using insulin-DNA origami nanostructures
Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
Conference publication: WOUND REPAIR AND REGENERATION. 2023;31:S19
STEM CELL-DERIVED HEPATOCYTE-LIKE CELLS RECAPITULATE CUES OF INSULIN RESISTANCE PROGRESSION
Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Jannig PR; Morais VA; Ruas JL; Miranda JP
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Preprint: BIORXIV. 2023
The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Pham TCP; Raun SH; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig P; Andersen NR; Kruse R; Ali MS; Halling JF; Ringholm S; Needham E; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Preprint: BIORXIV. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth B; Leiwe M; Minogue E; Cunha P; Engman V; Brombach C; Asvestis C; Sah-Teli S; Marklund E; Koivunen P; Ruas J; Rundqvist H; Lanner J; Johnson R
Conference publication: TOXICOLOGY LETTERS. 2023;384:S188
The role of glucose homeostasis and glucocorticoid signalling for the development of relevant hepatic in vitro models for toxicology, drug metabolism and energy metabolism studies
Saraiva Rodrigues J; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Conference publication: ACTA PHYSIOLOGICA. 2023;239
Control of cell-cell communication during muscle remodeling and regeneration by a novel RNA-binding protein
Ruas J
Journal article: TOXICOLOGY LETTERS. 2023;384(Front. Cell Dev. Biol. 9 2021):s188-S193
P16-19: The role of glucose homeostasis and glucocorticoid signalling for the development of relevant hepatic in vitro models for toxicology, drug metabolism and energy metabolism studies
Rodrigues JS; Faria-Pereira A; Camões SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Conference publication: ACTA PHYSIOLOGICA. 2023;239
Can PGC-1α1 counteract skeletal muscle capillary rarefaction and reduced glucose uptake induced by chronic inflammation?
Jude B; Tagadirt L; Santos-Alves E; Mader T; Chibalin AV; Ducommun S; Zierath JR; Von Walden F; Krook A; Ruas JL; Lanner JT
Journal article: ENDOCRINOLOGY. 2023;164(10):bqad128
Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice
Correia CM; Praestholm SM; Havelund JF; Pedersen FB; Siersbaek MS; Ebbesen MF; Gerhart-Hines Z; Heeren J; Brewer J; Larsen S; Blagoev B; Faergeman NJ; Grontved L
Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:85
The Tryptophan-Kynurenine pathway in the control of energy metabolism
Ruas JL
Preprint: BIORXIV. 2023;BIORXIV
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.
Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839
SKELETAL MUSCLE PGC1.1 PREVENTS ARTHRITIS-INDUCED CAPILLARY RAREFACTION AND IMPAIRED GLUCOSE UPTAKE
Jude B; Chibalin A; Ducommun S; Zierath J; Von Walden F; Ruas J; Krook A; Lanner J
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S741
Uncovering a novel potential target in non-alcoholic fatty liver disease
Praestholm SM; Correia J; Ruas J
Article: CELL REPORTS. 2023;42(1):112021
Epiblast-like stem cells established by Wnt/(3-catenin signaling manifest distinct features of formative pluripotency and germline competence
Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
Article: FRONTIERS IN ENDOCRINOLOGY. 2023;13:1043543
Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling
Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Corrigendum: NATURE METABOLISM. 2022;4(10):1421
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CELLS. 2022;11(19):2944
PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes
Tuomainen T; Naumenko N; Mutikainen M; Shakirzyanova A; Sczelecki S; Estall JL; Ruas JL; Tavi P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(9):102328
Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias
Schihada H; Klompstra TM; Humphrys LJ; Cervenka I; Dadvar S; Kolb P; Ruas JL; Schulte G
Article: BMC BIOLOGY. 2022;20(1):169
Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity
Oehler D; Spychala A; Godecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Conference publication: FEBS OPEN BIO. 2022;12:34
Novel players in the regulation of muscle mass, strength, and regeneration
Ruas J
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CARDIOVASCULAR RESEARCH. 2022;118(6):1520-1534
PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice
Naumenko N; Mutikainen M; Holappa L; Ruas JL; Tuomainen T; Tavi P
Conference publication: FASEB JOURNAL. 2022;36
Ruxolitinib Prevents Ventilator Induced Diaphragm Dysfunction
Addinsall AB; Cacciani N; Akkad H; Moruzzi N; Maestri A; Shevchenko G; Bergquist J; Ruas J; Larsson L
Editorial: CELL. 2022;185(8):1444-1444.e1
Regulation and biology of PGC-1α
Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(638):eaba9112
HIF-1α inhibitor PX-478 preserves pancreatic. cell function in diabetes
Ilegems E; Bryzgalova G; Correia J; Yesildag B; Berra E; Ruas JL; Pereira TS; Berggren P-O
Preprint: BIORXIV. 2022
Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity
Oehler D; Spychala A; Gödecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Journal article: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. 2022;32(1):10440
The 2022 On-site Padua Days on Muscle and Mobility Medicine hosts the University of Florida Institute of Myology and the Wellstone Center, March 30 - April 3, 2022 at the University of Padua and Thermae of Euganean Hills, Padua, Italy: The collection of abstracts.
Sweeney HL; Masiero S; Carraro U
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):64
Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model.
Severin F; Urbani A; Varanita T; Bachmann M; Azzolini M; Martini V; Pizzi M; Tos APD; Frezzato F; Mattarei A; Ghia P; Bertilaccio MTS; Gulbins E; Paradisi C; Zoratti M; Semenzato GC; Leanza L; Trentin L; Szabò I
Preprint: SSRN ELECTRONIC JOURNAL. 2022
Epiblast-Like Stem Cells Established by Wnt/β-Catenin Signaling Manifest Distinct Features of Formative Pluripotency
Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Petropoulos S; Chen X; Ruas JL; Wu J; Deng Q
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;322(1):C49-C62
Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism
Jonsson WO; Ponette J; Horwath O; Rydenstam T; Soderlund K; Ekblom B; Azzolini M; Ruas JL; Blomstrand E
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021;2021:7658501
Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene
La Spina M; Azzolini M; Salmaso A; Parrasia S; Galletta E; Schiavone M; Chrisam M; Mattarei A; Di Benedetto G; Ballabio A; Tiso N; Zoratti M; Biasutto L
Article: FASEB JOURNAL. 2021;35(12):e22010
Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force
Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
Doctoral thesis: 2021
The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
Dadvar S
Journal article: CELL REPORTS. 2021;37(5):109938
Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage
Praestholm SM; Correia CM; Goitea VE; Siersbaek MS; Jorgensen M; Havelund JF; Pedersen TA; Faergeman NJ; Grontved L
Article: CELL METABOLISM. 2021;33(11):2215-2230.e8
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Article: NATURE COMMUNICATIONS. 2021;12(1):5948
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
Corrigendum: REDOX BIOLOGY. 2021;45:102036
Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family (vol 37, 101705, 2020)
Peruzzo R; Mattarei A; Azzolini M; Becker-Flegler KA; Romio M; Rigoni G; Carrer A; Biasutto L; Parrasia S; Kadow S; Manag A; Urbani A; Rossa A; Semenzato G; Soriano ME; Trentin L; Ahmad S; Edwards M; Gulbins E; Paradisi C; Zoratti M; Leanza L; Szabo I
Article: METABOLITES. 2021;11(8):508
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
Article: BIOTECHNOLOGY AND BIOENGINEERING. 2021;118(6):2234-2242
Effects of topological constraints on the alignment and maturation of multinucleated myotubes
Song K-Y; Correia JC; Ruas JL; Teixeira AI
Preprint: BIORXIV. 2021
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Svaikovskaya D; Zhengye L; Cervenka I; Oliveira M; Nijssen J; Martínez-Redondo V; Stec M; Khan N; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Article: BMC BIOLOGY. 2021;19(1):57
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling
Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
Article: SCIENTIFIC REPORTS. 2021;11(1):6453
High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
Moberg M; Apro W; Cervenka I; Ekblom B; van Hall G; Holmberg H-C; Ruas JL; Blomstrand E
Article: NATURE COMMUNICATIONS. 2021;12(1):1026
Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice
Wu H; Petitpre C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3582
Full-length-transcriptomic analysis in mice and human heart using Single-Molecule Real-time Sequencing (SMRT) identified 15 novel isoforms and a novel promoter region of PGC1-alpha
Oehler D; Goedecke A; Spychala A; Lai K; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476
Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats
Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
Journal article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:572981
Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism
Praestholm SM; Correia CM; Grontved L
Article: REDOX BIOLOGY. 2020;37:101705
Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
Peruzzo R; Mattarei A; Azzolini M; Becker-Flegler KA; Romio M; Rigoni G; Carrer A; Biasutto L; Parrasia S; Kadow S; Manago A; Urbani A; Rossa A; Semenzato G; Soriano ME; Trentin L; Ahmad S; Edwards M; Gulbins E; Paradisi C; Zoratti M; Leanza L; Szabo I
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):541
Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes
Hahn M; van Krieken PP; Nord C; Alanentalo T; Morini F; Xiong Y; Eriksson M; Mayer J; Kostromina E; Ruas JL; Sharpe J; Pereira T; Berggren P-O; Ilegems E; Ahlgren U
Article: MOLECULAR METABOLISM. 2020;39:101012
Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN
Alves CRR; das Neves W; de Almeida NR; Eichelberger EJ; Jannig PR; Voltarelli VA; Tobias GC; Bechara LRG; Faria DDP; Alves MJN; Hagen L; Sharma A; Slupphaug G; Moreira JBN; Wisloff U; Hirshman MF; Negrao CE; de CGJ; Chammas R; Swoboda KJ; Ruas JL; Goodyear LJ; Brum PC
Article: NURSING OPEN. 2020;7(5):1446-1452
A qualitative study-Patient experience of tactile massage after stroke
Cronfalk BS; Akesson E; Nygren J; Nystrom A; Strandell A-M; Ruas J; von Euler M
Journal article: SCIENTIFIC REPORTS. 2020;10(1):14052
C57BL/6J substrain differences in response to high-fat diet intervention
Siersbaek MS; Ditzel N; Hejbol EK; Praestholm SM; Markussen LK; Avolio F; Li L; Lehtonen L; Hansen AK; Schroder HD; Krych L; Mandrup S; Langhorn L; Bollen P; Grontved L
Journal article: PLOS GENETICS. 2020;16(5):e1008770
Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone
Praestholm SM; Siersbaek MS; Nielsen R; Zhu X; Hollenberg A; Cheng S-Y; Grontved L
Editorial: SCIENCE. 2020;368(6490):470-471
Exercised cytokines promote endurance
Correia JC; Ruas JL
Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(5):C818-C830
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain
Martin KS; Azzolin M; Ruas JL
Article: MOLECULAR METABOLISM. 2020;34:72-84
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Leveille M; Besse-Patin A; Jouvet N; Gunes A; Sczelecki S; Jeromson S; Khan NP; Baldwin C; Dumouchel A; Correia JC; Jannig PR; Boulais J; Ruas JL; Estall JL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986
Modeling the transport of nuclear proteins along single skeletal muscle cells
Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
Article: REDOX BIOLOGY. 2020;28:101387
Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status
Peleli M; Ferreira DMS; Tarnawski L; Haworth SM; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlstrom M
Review: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019;181:111557
Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds
Biasutto L; Mattarei A; La Spina M; Azzolini M; Parrasia S; Szabo I; Zoratti M
Article: SKELETAL MUSCLE. 2019;9(1):26
LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force
Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(21):E5377-5377
Browning Effects of a Chronic Pterostilbene Supplementation in Mice Fed a High-Fat Diet
La Spina M; Galletta E; Azzolini M; Gomez Zorita S; Parrasia S; Salvalaio M; Salmaso A; Biasutto L
Conference publication: TOXICOLOGY LETTERS. 2019;314:S288
Hepatocyte-like cells in microfluidic devices: a new platform for disease modelling, drug screening and toxicology
Rodrigues JS; Cipriano M; Correia J; Camoes SP; Oliveira N; Castro M; Ruas J; Miranda J
Preprint: BIORXIV. 2019
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Jeromson S; Khan NP; Sczelecki S; Baldwin C; Dumouchel A; Correia J; Jannig P; Boulais J; Ruas JL; Estall JL
Article: MOLECULAR METABOLISM. 2019;25:159-167
Epigenetic regulation of diabetogenic adipose morphology
Kerr AG; Sinha I; Dadvar S; Arner P; Dahlman I
Article: NATURE COMMUNICATIONS. 2019;10(1):2767
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
Article: CELLULAR SIGNALLING. 2019;57:45-57
Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates
Ducommun S; Deak M; Zeigerer A; Goransson O; Seitz S; Collodet C; Madsen AB; Jensen TE; Viollet B; Foretz M; Gut P; Sumpton D; Sakamoto K
Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2019;52(2):232-239
Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study.
La Spina M; Sansevero G; Biasutto L; Zoratti M; Peruzzo R; Berardi N; Sale A; Azzolini M
Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13
Activation of the Unfolded Protein Response in Parkinson's disease
Carvalho A; Ranito C; Tavares C; Castro-Caldas M; Rodrigues E; Ruas J; Van Horssen J; Gama M
Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13
Unanswered role of cholesterol homeostasis in Parkinson’s disease
Nunes M; Caria I; Carvalho A; Costa D; Castro-Caldas M; Gama M; Rodrigues E; Ruas J
Article: CARDIOVASCULAR RESEARCH. 2019;115(1):107-118
Heart specific PGC-1 deletion identifies metabolome of cardiac restricted metabolic heart failure
Karkkainen O; Tuomainen T; Mutikainen M; Lehtonen M; Ruas JL; Hanhineva K; Tavi P
Journal article: PLOS BIOLOGY. 2018;16(12):e2006249
Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver
Kalvisa A; Siersbaek MS; Praestholm SM; Christensen LJL; Nielsen R; Stohr O; Vettorazzi S; Tuckermann J; White M; Mandrup S; Grontved L
Article: PHYSIOLOGICAL GENOMICS. 2018;50(12):1071-1082
Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
Blackwell TA; Cervenka I; Khatri B; Brown JL; Rosa-Caldwell ME; Lee DE; Perry RAJ; Brown LA; Haynie WS; Wiggs MP; Bottje WG; Washington TA; Kong BC; Ruas JL; Greene NP
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):519-533
The weight of nutrients: kynurenine metabolites in obesity and exercise
Dadvar S; Ferreira DMS; Cervenka I; Ruas JL
Article: EMBO MOLECULAR MEDICINE. 2018;10(8):e8613
Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors
Bayindir-Buchhalter I; Wolff G; Lerch S; Sijmonsma T; Schuster M; Gronych J; Billeter AT; Babaei R; Krunic D; Ketscher L; Spielmann N; de Angelis MH; Ruas JL; Mueller-Stich BP; Heikenwalder M; Lichter P; Herzig S; Vegiopoulos A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;500(1):51-58
Mitochondrial potassium channels in cell death
Checchetto V; Azzolini M; Peruzzo R; Capitanio P; Leanza L
Journal article: IBJ PLUS. 2018
Exploring the regulation of frataxin expression by neurotrophic factors in the mouse cerebellum after physical exercise.
Agró M; Díaz Nido J; Giménez Cassina A; Katsu Jiménez Y; da Silva P; Ruas J
Article: MOLECULAR METABOLISM. 2018;9:28-42
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration
Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
Article: CELL METABOLISM. 2018;27(2):378-392.e5
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Journal article: ANNALS OF RESEARCH IN SPORT AND PHYSICAL ACTIVITY. 2018;(ex2018):79-80
Effects of exercise training on kynurenines, metabolism, and mental health
Ruas JL
Article: MOLECULAR METABOLISM. 2018;7:12-22
Neurturin is a PGC-1 α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation
Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(52):E11323-E11332
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo
Hoenes GS; Rakov H; Logan J; Liao X-H; Werbenko E; Pollard AS; Praestholm SM; Siersbaek MS; Rijntjes E; Gassen J; Latteyer S; Engels K; Strucksberg K-H; Kleinbongard P; Zwanziger D; Rozman J; Gailus-Durner V; Fuchs H; de Angelis MH; Klein-Hitpass L; Koehrle J; Armstrong DL; Grontved L; Bassett JHD; Williams GR; Refetoff S; Fuehrer D; Moeller LC
Journal article: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. 2017;27(4):7218
Report and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology, - Assisi (Italy), October 12-15, 2017
Gabellini D; Musarò A
Review: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2017;1403(1):27-37
Resveratrol derivatives as a pharmacological tool
Biasutto L; Mattarei A; Azzolini M; La Spina M; Sassi N; Romio M; Paradisi C; Zoratti M
Review: SCIENCE. 2017;357(6349):eaaf9794
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health
Cervenka I; Agudelo LZ; Ruas JL
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2017;135:77-88
Novel lipid-mimetic prodrugs delivering active compounds to adipose tissue
Mattarei A; Rossa A; Bombardelli V; Azzolini M; La Spina M; Paradisi C; Zoratti M; Biasutto L
Article: ONCOTARGET. 2017;8(24):38276-38293
Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma
Zaccagnino A; Manago A; Leanza L; Gontarewitz A; Linder B; Azzolini M; Biasutto L; Zoratti M; Peruzzo R; Legler K; Trauzold A; Kalthoff H; Szabo I
Article: ARCHIVES OF TOXICOLOGY. 2017;91(6):2469-2489
The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells
Cipriano M; Correia JC; Camoes SP; Oliveira NG; Cruz P; Cruz H; Castro M; Ruas JL; Santos JM; Miranda JP
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2017;115:149-158
New natural amino acid-bearing prodrugs boost pterostilbene's oral pharmacokinetic and distribution profile
Azzolini M; Mattarei A; La Spina M; Fanin M; Chiodarelli G; Romio M; Zoratti M; Paradisi C; Biasutto L
Article: CANCER CELL. 2017;31(4):516-531.e10
Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo
Leanza L; Romio M; Becker KA; Azzolini M; Trentin L; Manago A; Venturini E; Zaccagnino A; Mattarei A; Carraretto L; Urbani A; Kadow S; Biasutto L; Martini V; Severin F; Peruzzo R; Trimarco V; Egberts J-H; Hauser C; Visentin A; Semenzato G; Kalthoff H; Zoratti M; Gulbins E; Paradisi C; Szabo I
Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17
The mitochondrial NDUFA4L2 protein: a novel modulator of skeletal muscle mass and force
Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
Conference publication: ACTA PHYSIOLOGICA. 2017;219:20
Moderate PGC-1α1 expression induces beneficial E-C coupling phenotype without metabolic remodelling
Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Hynynen H; Laidinen S; Yla-Herttuala S; Heinaniemi M; Ruas J; Tavi P
Article: DIABETOLOGIA. 2017;60(2):336-345
A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.
Chen Q; Xie B; Zhu S; Rong P; Sheng Y; Ducommun S; Chen L; Quan C; Li M; Sakamoto K; MacKintosh C; Chen S; Wang HY
Article: CELL REPORTS. 2017;18(3):636-646
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
Ruby MA; Massart J; Hunerdosse DM; Schonke M; Correia JC; Louie SM; Ruas JL; Naslund E; Nomura DK; Zierath JR
Book chapter: HORMONES, METABOLISM AND THE BENEFITS OF EXERCISE: RESEARCH AND PERSPECTIVES IN ENDOCRINE INTERACTIONS. 2017;p. 83-91
Tryptophan-Kynurenine Metabolites in Exercise and Mental Health
Valente-Silva P; Ruas JL
Article: BIOLOGICAL SIGNALS. 2017;25(1):26-38
Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells.
Venturini E; Leanza L; Azzolini M; Kadow S; Mattarei A; Weller M; Tabatabai G; Edwards MJ; Zoratti M; Paradisi C; Szabò I; Gulbins E; Becker KA
Editorial: ACTA PHYSIOLOGICA. 2017;219(1):14-16
Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise
Jannig PR; Ruas JL
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(23):7049-7071
Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling
Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Laidinen S; Kokki K; Hynynen H; Yla-Herttuala S; Heinaniemi M; Ruas JL; Tavi P
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186
NDUFA4L2-Connecting Metabolic Signals and Mitochondrial Function in Cardiac and Skeletal Muscle
Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1863(10):2515-2530
The mitochondrial permeability transition pore in AD 2016: An update
Biasutto L; Azzolini M; Szabo I; Zoratti M
Article: SCIENTIFIC REPORTS. 2016;6:30928
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Ruas JL; Rodrigues E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103
The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedstrom Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(15):4371-4388
Mechano-signalling pathways in an experimental intensive critical illness myopathy model
Kalamgi RC; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; Gromada J; Sartori R; Guttridge DC; Sandri M; Larsson L
Letter: ACTA NEUROPSYCHIATRICA. 2016;28(4):244-245
Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle
Zepf FD; Stewart RM; Guillemin GJ; Ruas JL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184
Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes
Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
Article: CELL METABOLISM. 2016;24(1):118-129
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.
Mottillo EP; Desjardins EM; Crane JD; Smith BK; Green AE; Ducommun S; Henriksen TI; Rebalka IA; Razi A; Sakamoto K; Scheele C; Kemp BE; Hawke TJ; Ortega J; Granneman JG; Steinberg GR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016;310(10):C836-C840
Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
Article: SKELETAL MUSCLE. 2016;6(1):30
Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Sakakibara I; Wurmser M; Dos Santos M; Santolini M; Ducommun S; Davaze R; Guernec A; Sakamoto K; Maire P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497
Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca²⁺ leak after one session of high-intensity interval exercise
Place N; Ivarsson N; Venckunas T; Neyroud D; Brazaitis M; Cheng AJ; Ochala J; Kamandulis S; Girard S; Volungevicius G; Pauzas H; Mekideche A; Kayser B; Martinez-Redondo V; Ruas JL; Bruton J; Truffert A; Lanner JT; Skurvydas A; Westerblad H
Article: MOLECULAR METABOLISM. 2015;4(12):891-902
Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: SCIENTIFIC REPORTS. 2015;5:15216
Amino Acid Carbamates As Prodrugs Of Resveratrol
Mattarei A; Azzolini M; La Spina M; Zoratti M; Paradisi C; Biasutto L
Article: MOLECULAR PHARMACEUTICS. 2015;12(9):3441-3454
Synthesis and Evaluation as Prodrugs of Hydrophilic Carbamate Ester Analogues of Resveratrol
Azzolini M; Mattarei A; La Spina M; Marotta E; Zoratti M; Paradisi C; Biasutto L
Article: MOLECULES. 2015;20(9):16085-16102
N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol
Mattarei A; Azzolini M; Zoratti M; Biasutto L; Paradisi C
Conference publication: DIABETOLOGIA. 2015;58:S300
Acute exercise impacts kynurenine metabolism in type 2 diabetic and healthy people
Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Review: DIABETOLOGIA. 2015;58(9):1969-1977
The hitchhiker's guide to PGC-1α isoform structure and biological functions
Martinez-Redondo V; Pettersson AT; Ruas JL
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314
Intercellular: local and systemic actions of skeletal muscle PGC-1s
Correia JC; Ferreira DMS; Ruas JL
Article: CELLULAR SIGNALLING. 2015;27(5):978-988
Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.
Ducommun S; Deak M; Sumpton D; Ford RJ; Núñez Galindo A; Kussmann M; Viollet B; Steinberg GR; Foretz M; Dayon L; Morrice NA; Sakamoto K
Corrigendum: CELL. 2015;160(1-2):351
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression (vol 159, pg 33, 2014)
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2014;14(10):1332-1342
Improving the Efficacy of Plant Polyphenols
Biasutto L; Mattarei A; Sassi N; Azzolini M; Romio M; Paradisi C; Zoratti M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(44):15756-15761
G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy
White JP; Wrann CD; Rao RR; Nair SK; Jedrychowski MP; You J-S; Martinez-Redondo V; Gygi SP; Ruas JL; Hornberger TA; Wu Z; Glass DJ; Piao X; Spiegelman BM
Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2014;58(11):2122-2132
Pharmacokinetics and tissue distribution of pterostilbene in the rat
Azzolini M; La Spina M; Mattarei A; Paradisi C; Zoratti M; Biasutto L
Article: MOLECULES. 2014;19(10):15900-15917
New Water-Soluble Carbamate Ester Derivatives of Resveratrol
Mattarei A; Carraro M; Azzolini M; Paradisi C; Zoratti M; Biasutto L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1837(10):1781-1789
Cytotoxicity of mitochondria-targeted resveratrol derivatives: Interactions with respiratory chain complexes and ATP synthase
Sassi N; Mattarei A; Azzolini M; Szabo' I; Paradisi C; Zoratti M; Biasutto L
Article: CELL. 2014;159(1):33-45
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: CELL. 2014;157(6):1279-1291
Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Rao RR; Long JZ; White JP; Svensson KJ; Lou J; Lokurkar I; Jedrychowski MP; Ruas JL; Wrann CD; Lo JC; Camera DM; Lachey J; Gygi S; Seehra J; Hawley JA; Spiegelman BM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(6):E688-E696
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.
Ducommun S; Ford RJ; Bultot L; Deak M; Bertrand L; Kemp BE; Steinberg GR; Sakamoto K
Article: MOLECULAR CANCER. 2014;13:54
Regulation of CDKN2B expression by interaction of Arnt with Miz-1-a basis for functional integration between the HIF and Myc gene regulatory pathways
Aesoy R; Gradin K; Aasrud KS; Hoivik EA; Ruas JL; Poellinger L; Bakke M
Article: CURRENT PHARMACEUTICAL DESIGN. 2014;20(2):172-179
Mitochondria-targeted Resveratrol Derivatives Act as Cytotoxic Pro-oxidants
Sassi N; Mattarei A; Azzolini M; Bernardi P; Szabo I; Paradisi C; Zoratti M; Biasutto L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167
Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL
Article: MOLECULAR PHARMACEUTICS. 2013;10(7):2781-2792
Acetal Derivatives as Prodrugs of Resveratrol
Mattarei A; Azzolini M; Carraro M; Sassi N; Zoratti M; Paradisi C; Biasutto L
Journal article: FASEB JOURNAL. 2013;27(S1):940.18
A novel PGC‐1á isoform induced by resistance training regulates skeletal muscle hypertrophy
White J; Ruas J; Rao R; Kleiner S; Wu J; Spiegelman B
Article: BIOCHEMICAL JOURNAL. 2013;449(2):479-489
AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.
Wang HY; Ducommun S; Quan C; Xie B; Li M; Wasserman DH; Sakamoto K; Mackintosh C; Chen S
Article: CELL. 2012;151(6):1319-1331
A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy
Ruas JL; White JP; Rao RR; Kleiner S; Brannan KT; Harrison BC; Greene NP; Wu J; Estall JL; Irving BA; Lanza IR; Rasbach KA; Okutsu M; Nair KS; Yan Z; Leinwand LA; Spiegelman BM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;302(9):E1036-E1043
Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.
Ducommun S; Wang HY; Sakamoto K; MacKintosh C; Chen S
Article: GENES & DEVELOPMENT. 2011;25(12):1232-1244
Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase
Lustig Y; Ruas JL; Estall JL; Lo JC; Devarakonda S; Laznik D; Choi JH; Ono H; Olsen JV; Spiegelman BM
Article: CELL METABOLISM. 2011;13(2):160-169
The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex
Wu J; Ruas JL; Estall JL; Rasbach KA; Choi JH; Ye L; Bostroem P; Tyra HM; Crawford RW; Campbell KP; Rutkowski DT; Kaufman RJ; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21866-21871
PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
Rasbach KA; Gupta RK; Ruas JL; Wu J; Naseri E; Estall JL; Spiegelman BM
Article: DEVELOPMENT. 2010;137(20):3489-3499
Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons
Chakkalakal JV; Nishimune H; Ruas JL; Spiegelman BM; Sanes JR
Article: NATURE. 2010;466(7305):451-456
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
Choi JH; Banks AS; Estall JL; Kajimura S; Bostroem P; Laznik D; Ruas JL; Chalmers MJ; Kamenecka TM; Blueher M; Griffin PR; Spiegelman BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(4):2601-2609
Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300
Ruas JL; Berchner-Pfannschmidt U; Malik S; Gradin K; Fandrey J; Roeder RG; Pereira T; Poellinger L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22510-22515
PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM
Article: CANCER BIOMARKERS. 2009;5(6):273-277
Ethnic variability of HIF-1alpha polymorphisms.
Ribeiro AL; Correia J; Ribeiro V
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(50):21401-21406
The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
Chinsomboon J; Ruas J; Gupta RK; Thom R; Shoag J; Rowe GC; Sawada N; Raghuram S; Arany Z
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):E16-E17
HIF-Independent Regulation of Angiogenesis in Ischemia and Exercise
Arany ZP; Foo S-Y; Chinsomboon J; Girnun G; Cooper M; Ruas J; Bommi-Reddy A; Rangwala S; Baek KH; Rosenzweig A; Spiegelman B
Article: GENES & DEVELOPMENT. 2008;22(10):1397-1409
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Kajimura S; Seale P; Tomaru T; Erdjument-Bromage H; Cooper MP; Ruas JL; Chin S; Tempst P; Lazar MA; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: NATURE. 2008;451(7181):1008-1012
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany Z; Foo S-Y; Ma Y; Ruas JL; Bommi-Reddy A; Girnun G; Cooper M; Laznik D; Chinsomboon J; Rangwala SM; Baek KH; Rosenzweig A; Spiegelman BM
Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514
Modular of vascular gene expression by hypoxia
Ruas JL; Lendahl U; Poellinger L
Article: FASEB JOURNAL. 2007;21(8):1821-1830
Hypoxia inducible factor regulates the cardiac expression and secretion of apelin
Ronkainen V-P; Ronkainen JJ; Hannninen SL; Leskinen H; Ruas JL; Pereira T; Poellinger L; Vuolteenaho O; Tavi P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α:: Role of subcellular compartmentalization
Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):514-522
Hypoxia-dependent activation of HIF into a transcriptional regulator
Ruas JL; Poellinger L
Doctoral thesis: 2005
Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1
Ruas JL
Article: JOURNAL OF CELL SCIENCE. 2005;118(2):301-311
Role of CBP in regulating HIF-1-mediated activation of transcription
Ruas JL; Poellinger L; Pereira T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823
Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor gene product
Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(41):38723-38730
Functional analysis of hypoxia-inducible factor-1α-mediated transactivation -: identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein
Ruas JL; Poellinger L; Pereira T
Article: PHARMACOGENETICS AND GENOMICS. 1997;7(4):333-335
Allele frequency of CYP2C19 in a Portuguese population
Ruas JL; Lechner MC
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